Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 276684-04-9, is researched, Molecular C10H6Cl2N2O2, about Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents, the main research direction is amidopodophyllotoxin heteroaromatic linked preparation anticancer activity apoptosis.Formula: C10H6Cl2N2O2.
A series of different heteroaromatic linked 4β-amidopodophyllotoxin conjugates were synthesized and evaluated for anticancer activity against five human cancer cell lines. Among the series, one of the compound I showed significant antiproliferative activity in A549 (lung cancer) cell line. Flow cytometric anal. showed that I arrested the cell cycle in the G2/M phase leading to caspase-3 dependent apoptotic cell death. Further, Hoechst 33258 staining and DNA fragmentation assay also suggests that I induces cell death by apoptosis.
I hope my short article helps more people learn about this compound(5-(3,4-Dichlorophenyl)-1H-pyrazole-3-carboxylic acid)Formula: C10H6Cl2N2O2. Apart from the compound(276684-04-9), you can read my other articles to know other related compounds.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia