Zasosov, V. A.; Nikulina, T. N.; Blinova, L. S.; Onoprienko, V. S.; Sycheva, V. N.; Sokolova, G. N.; Borodina, K. S.; Denisova, K. V. published the artcile< Synthesis of 4-(p-aminobenzenesulfonamido)-5,6-dimethoxypyrimidine>, Synthetic Route of 5018-38-2, the main research area is amino benzenesulfonamido methoxy pyrimidine; sulfamide pyrimidyl.
CO2H)2 was esterified with MeOH and then treated with MeOCH2CO2CO2Me(from ClCH2CO2Me and NaOMe) to give MeO2CCH(OMe)COCO2Me, which was decarbonylated at 210° to give MeOCH(CO2Me)2. The latter reacted with NH3 and then HCONH2 in the presence of NaOEt to form the di-Na salt of 4,6-dihydroxy-5-methoxypyrimidine, which was converted to the 4,6-dichloro derivative (I) with POCl3 and PhNMe2. I reacted with NH3 in DMF to form the 4-amino derivative, which yielded 4-amino-5,6-dimethoxypyrimidine with NaOH in MeOH. The latter was converted to the title compound (II) by treatment with 4-MeO2CNHC6H4SO2Cl in pyridine, followed by hydrolysis with concentrated HCl.
Khimiko-Farmatsevticheskii Zhurnal published new progress about 5018-38-2. 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, Synthetic Route of 5018-38-2.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia