The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Synthetic Route of 109-12-6.
Zhang, Rui;Yao, Wei-Zhong;Qian, Liang;Sang, Wei;Yuan, Ye;Du, Min-Chen;Cheng, Hua;Chen, Cheng;Qin, Xin research published 《 A practical and sustainable protocol for direct amidation of unactivated esters under transition-metal-free and solvent-free conditions》, the research content is summarized as follows. In this paper, a NaOtBu-mediated synthesis approach was developed for direct amidation of unactivated esters RC(O)OR1 (R = Ph, pyridin-2-yl, cyclopropyl, Me, pyrazin-2-yl, etc.; R1 = Me, Et, Ph, etc.) with amines R2R3NH (R2 = Ph, n-hexyl, benzyl, etc.; R3 = H, Me; R2R3 = -(CH2)5-, -(CH2)2O(CH2)2-) under transition-metal-free and solvent-free conditions, affording a series of amides R(CO)NR2R3 in good to excellent yields at room temperature In particular, an environmentally friendly and practical workup procedure, which circumvents the use of organic solvents and chromatog. in most cases, was disclosed. Moreover, the gram-scale production of representative products R(CO)NR2R3 (R = Ph, R2 = Ph, 2-phenylethyl, R3 = H; R = Me, R2 = Ph, R3 = H) was efficiently realized by applying operationally simple, sustainable and practical procedures. Furthermore, this approach was also applicable to the synthesis of valuable mols. such as moclobemide (a powerful antidepressant), benodanil and fenfuram (two com. agricultural fungicides). These results demonstrate that this protocol has the potential to streamline amide synthesis in industry. Meanwhile, quant. green metrics of all the target products were evaluated, implying that the present protocol is advantageous over the reported ones in terms of environmental friendliness and sustainability. Finally, addnl. experiments and computational calculations were carried out to elucidate the mechanistic insight of this transformation, and one plausible mechanism was provided on the basis of these results and the related literature reports.
109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Synthetic Route of 109-12-6
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia