Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 1722-12-9, formula is C4H3ClN2, Name is 2-Chloropyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Category: pyrimidines.
Zhang, Weigang;Huang, Mengjun;Zou, Zhenlei;Wu, Zhengguang;Ni, Shengyang;Kong, Lingyu;Zheng, Youxuan;Wang, Yi;Pan, Yi research published 《 Redox-active benzimidazolium sulfonamides as cationic thiolating reagents for reductive cross-coupling of organic halides》, the research content is summarized as follows. Redox-active benzimidazolium sulfonamides I (Ar = 4-methylphenyl, 2-[methoxy(oxo)methane]thiophen-3-yl, naphthalen-1-yl, etc.; R = H; R1 = H; RR1 = -CH-C=C-CH-) as thiolating reagents have been developed for reductive C-S bond coupling. The benzimidazolium sulfonamides I reagent provides a bench-stable cationic precursor to generate a portfolio of highly active N-S intermediates, which can be successfully applied in cross-electrophilic coupling with various organic halides R2X (X = I, Cl, Br; R2 = hex-5-en-1-yl, 4-(trifluoromethoxy)phenyl, 1H-indol-5-yl, pyrimidin-2-yl, etc.). The employment of an electrophilic sulfur source solved the problem of catalyst deactivation and avoided odorous thiols, featuring practical conditions, broad substrate scope, and excellent tolerance.
Category: pyrimidines, 2-Chloropyrimidine is a monochlorinated pyrimidine with plant growth regulating activity. Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds.
2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.
2-Chloropyrimidine is a molecule that can be synthesized by the oxidation of pyrimidine with hydrogen peroxide and hydrochloric acid. The reaction proceeds through an electrochemical process in which the oxidation catalyst is a platinum electrode. This reaction is catalyzed by the nucleophilic attack of malonic acid on the chloropyrimidine at the methylene group. This efficient method for making 2-chloropyrimidine has been applied to synthesize aryl halides, including phenyl chloropyrimidine and pyridyl chloropyrimidine, from their corresponding chloride and bromide precursors. The fluorescence properties of 2-chloropyrimidine have been studied in coordination chemistry, where it forms complexes with metal ions such as Mn2+. In this study, it was found that adsorption mechanisms are dependent on molecular size, charge density, kinetic energy, and adsorbent surface area., 1722-12-9.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia