On May 10, 2022, Zhang, Xuejun; Chang, Shaohua; Lei, Sijun; Ding, Xiaohua; Chen, Haomin; Jing, Zhenzhong; Yang, Chengbing; Liu, Lifei; Yang, Jun; Li, Lie published a patent.Name: 2-Chloro-5-isopropylpyrimidine The title of the patent was Preparation of nitrogen-substituted heterocyclic thiophenes and their uses in preparation of a medicament for the treatment of LPAR-related diseases. And the patent contained the following:
The present invention relates to the preparation of nitrogen-substituted heterocyclic thiophenes and their uses in preparation of a medicament for the treatment of LPAR-related diseases. In particular, the nitrogen-substituted heterocyclic thiophene compound I (wherein, R1 = -H, -CN, halogen, -Z-Ra, the following groups (un)substituted by Rb: C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkylamino, C1-6 alkoxy; Z = single bond, -O-, -S- or -CO-; Ra is = C1-6 alkyl, C1-6 alkyl substituted by halogen, amino, C1-3 alkylamino; Rb = -CN, halogen, C1-6 alkyl, C1-6 alkoxy groups; R2 = -H, -CN, halogen, -Y-Rd, the following groups (un)substituted by Re: C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkylamino, C1-6 alkoxy; Y = single bond or -O-, -S-; Rd = C1-6 alkyl, C1-6 alkyl group substituted by halogen; Re = -CN, halogen, C1-6 alkyl, C1-6 alkoxy groups). Further, ( X1, X2, X3 = C or N, and X1, X2, X3 = not N at the same time; Rg is selected from H, F, Cl, methyl; L1 = single bond, -N(R3)- or -O-; L2 = single bond, -O-, C1-6 alkylene (un)substituted by C1-3 alkyl, unsubstituted or cyclopropyl substituted by C1-3 alkyl; R3 = -H, C1-3 alkyl; R4 = -H, -CN, halogen, the following groups (un)substituted by Rh: C1-6 alkyl, C3-8 cycloalkyl; and Rh = -H, halogen, C1-6 alkyl, C1-6 alkyl substituted by halogen, C1-6 alkoxy substituted by halogen groups) was prepared The compound of the present invention has good antagonism to LPAR1, and has good antagonism to LPAR3. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Name: 2-Chloro-5-isopropylpyrimidine
The Article related to nitrogen substituted heterocyclic thiophene preparation lpar antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: 2-Chloro-5-isopropylpyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia