Zhao, Y. published the artcileSynthesis and In Vitro Evaluation of Bis-intercalators with Varied Linkers between Aminochloropyrimidine Rings, Application of 2-Amino-4,6-dichloropyrimidine, the publication is Journal of Heterocyclic Chemistry (2014), 51(5), 1327-1332, database is CAplus.
The synthesis of two groups of aminochloropyrimidine bis-intercalators with different lipophilicity or limited flexibility of linkers as potential DNA intercalators is described. The lipophilic linkers in the synthesized bis-intercalators are represented by alternating methylene groups and oxygen atoms in a chain, with a pyrimidine ring containing an amino group and a chloro group at each end I [X = (CH2)2O(CH2)2O(CH2)2, (CH2)3O(CH2)2O(CH2)3, (CH2)3O(CH2)4O(CH2)3, (CH2)3O(CH2)2O(CH2)2O(CH2)3]. The bis-intercalators with limited flexibility contain chains with two benzene rings II [Y = CH2C6H4CH2, C6H4CH2C6H4, C6H4(CH2)2C6H4, C6H4OC6H4, C6H4SC6H4]. All compounds I, II were obtained by nucleophilic substitution of 2-amino-4,6-dichloropyrimidine. The anticancer activity of these newly synthesized compounds I, II is also reported. The compounds III (n = 10, 12) described in one of our previous publications display good anticancer activity against murine lymphoma.
Journal of Heterocyclic Chemistry published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C3H5BN2O2, Application of 2-Amino-4,6-dichloropyrimidine.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia