The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Recommanded Product: 5-Bromopyrimidine.
Zheng, Di-Zhong;Li, Dong-Hui;Liu, Huan;Shao, Youxiang;Ke, Zhuofeng;Liu, Feng-Shou research published 《 Bis(imino)acenaphthene (BIAN)-Supported N-Heterocyclic Carbene Palladium Complexes with Ancillary Ligands: Readily Activated Precatalysts for Direct C-H Arylation of Thiophenes》, the research content is summarized as follows. The authors report herein a highly efficient direct C-H arylation of thiophenes with (hetero)aryl bromides by bulky bis(imino)acenaphthene (BIAN)-supported N-heterocyclic carbene Pd complexes. The relation between the structure of Pd complexes with ancillary ligands and catalytic properties is discussed. Upon a low Pd loading of 0.01-0.05 mol %, the bulky Pd complex was successfully used to catalyze the cross-coupling of a variety of thiophenes with (hetero)aryl bromides under aerobic conditions. Also, it provides a practical and straightforward access to poly(3-hexylthiophenes) with high mol. weight and high HT value under aerobic reaction conditions. To access the mechanistic of the transformation, experiment study and DFT calculations on the direct arylation were performed, which supported the involvement of a Pd(0)/Pd(II) CMD process.
4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., Recommanded Product: 5-Bromopyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia